Advanced Cellular Detoxification and Immune Reset with Dr. Phillip Milgram, MD
Therapeutic Plasma Exchange (TPE) is a powerful, evidence-based medical procedure that removes harmful substances from the bloodstream to reduce inflammation, support immune function, and promote systemic rejuvenation. Now offered at AgeReversalMD under the direction of Dr. Phillip Milgram, MD, TPE is available as part of a comprehensive, physician-guided approach to treating autoimmune, neurological, and age-related conditions.
Over 200 therapeutic plasma exchange procedures performed!
Dr. Milgram brings over 47 years of clinical experience to this advanced therapy. A former Clinical Instructor and Assistant Clinical Professor at the UCSD School of Medicine’s Department of Reproductive Medicine, Dr. Milgram holds three degrees from UCSD in Advanced Intervention and is a member of both the American College of Preventive Medicine and the American Nutraceutical Association. His leadership ensures that every TPE protocol at AgeReversalMD is grounded in clinical rigor, safety, and personalized care.
What Is Therapeutic Plasma Exchange?
Therapeutic Plasma Exchange is a specialized procedure that filters the blood to remove disease-causing and age-accelerating components. During a TPE session:
- Blood is drawn from the patient and passed through a medical device called an apheresis machine
- The machine separates and removes the plasma—the liquid portion of the blood that contains inflammatory proteins, autoantibodies, and toxins
- The plasma is replaced with a sterile albumin solution
- The cleansed blood is returned to the patient’s body
Plasma makes up about 55% of total blood volume and plays a vital role in transporting nutrients, hormones, and waste products. However, it also carries immune complexes, cytokines, and other molecules that can contribute to chronic inflammation, autoimmune activity, and cellular aging. By removing and replacing this plasma, TPE offers a targeted, systemic reset.
Who Can Benefit from TPE?
Dr. Phillip Milgram recommends TPE for a wide range of patients, including those with:
- Autoimmune diseases such as lupus, myasthenia gravis, Guillain-Barré syndrome, and ANCA vasculitis
- Neurological conditions including chronic inflammatory demyelinating polyneuropathy (CIDP), neuromyelitis optica (NMOSD), and autoimmune encephalitis
- Post-viral syndromes, including Long COVID and chronic fatigue
- Elevated lipoprotein(a) and other cardiovascular risk factors
- Chronic inflammation, brain fog, and metabolic dysfunction
- Age-related immune decline and those seeking longevity optimization
TPE is also used in hospital settings to treat over 80 conditions, including thrombotic thrombocytopenic purpura (TTP), cryoglobulinemia, and antibody-mediated transplant rejection. At AgeReversalMD, it is offered as both a therapeutic and preventative intervention.
Clinical Evidence: The Circulate Trial
In 2024, Circulate published a landmark clinical study evaluating the effects of TPE—with and without intravenous immunoglobulin (IVIG)—on biological aging and immune function. The Circulate Trial followed participants over a two-year period and included four groups:
| Group | Treatment Protocol |
|---|---|
| Group 1 | TPE once a month for six months |
| Group 2 | TPE twice a month (same week) for three months |
| Group 3 | TPE with IVIG twice a month (same week) for three months |
| Control | No TPE or IVIG (placebo) |
Researchers measured biological age using 38 validated biological clocks and over 3,000 biomarkers related to inflammation, metabolism, and immune health. They also assessed physical performance, including strength and balance.
Key Findings
- Biological Age Reduction: Group 3 (TPE + IVIG) experienced an average 2.6-year decrease in biological age after just three sessions
- Immune System Reset: TPE + IVIG increased protective CD8 and CD4 naïve T cells and reduced inflammatory NK cells and monocytes
- Molecular Improvements: Participants showed improved protein and lipid profiles and reduced inflammatory markers
- Broad Benefit: Both healthy and at-risk individuals benefited. Those with elevated blood sugar and liver enzymes saw the greatest biological age reduction, while healthy individuals experienced improved vitality, strength, and balance
These results support TPE as a promising intervention for both disease management and preventative health.
What to Expect During Treatment
Each TPE session with Dr. Phillip Milgram lasts approximately 2 to 3 hours. The procedure is performed in a comfortable clinical setting with continuous monitoring by trained medical staff. Most patients report little to no discomfort, aside from mild coldness or brief needle insertion.
Before your session:
- Stay well-hydrated for 1–2 days prior
- Avoid alcohol the day before
- Eat a light meal before arriving
- Wear loose, comfortable clothing
After your session:
- Most patients can resume normal activities
- Mild fatigue or chills may occur—rest and hydration are recommended
- Avoid strenuous exercise for the remainder of the day
- Avoid any alcohol for 48-72hrs
How Many Treatments Are Needed?
Treatment frequency depends on your condition and goals. Dr. Milgram will create a personalized plan, which may include:
- Initial series: 1 to 6 sessions over several weeks
- Maintenance: Quarterly or biannual sessions for ongoing support
Patients with autoimmune or neurological conditions may require more frequent sessions initially, while those pursuing longevity or detoxification may benefit from periodic maintenance.
Benefits of Therapeutic Plasma Exchange
Patients undergoing TPE with Dr. Phillip Milgram may experience:
- Reduced systemic inflammation
- Improved cognitive clarity and memory
- Enhanced cardiovascular and metabolic health
- Detoxification of immune complexes and toxins
- Strengthened immune resilience
- Improved energy, strength, and physical performance
- Reduction in biological age and improved aging biomarkers
TPE is also being explored as a supportive therapy for hormone optimization, regenerative medicine, and post-viral recovery.
Safety and Side Effects
TPE is a well-established, FDA-cleared procedure with a strong safety profile. Side effects are rare and typically mild. These may include:
- Low blood pressure
- Dizziness or lightheadedness
- Mild allergic reactions to replacement fluids
- Temporary fatigue or chills
- Infection risk (if using a catheter)
Dr. Milgram and his team follow strict safety protocols and provide continuous monitoring to ensure a safe and comfortable experience.
TPE vs. IVIG: Complementary Therapies
While TPE removes harmful antibodies and inflammatory proteins, IVIG replenishes the bloodstream with healthy, functional antibodies. In certain autoimmune or immune-compromised cases, Dr. Phillip Milgram may recommend IVIG following TPE to restore immune balance and enhance therapeutic outcomes.
| Feature | TPE | IVIG |
|---|---|---|
| Mechanism | Removes pathogenic antibodies and toxins | Replaces and modulates immune response |
| Duration | 2–3 hours per session | 1–2 hours per infusion |
| Use Cases | Autoimmune, neurological, detox, anti-aging | Autoimmune, post-TPE immune support |
| Regulation | FDA-cleared | FDA-approved |
Is TPE Right for You?
If you are managing a chronic condition, recovering from a viral illness, or seeking to optimize your longevity, Therapeutic Plasma Exchange may offer transformative benefits. Dr. Phillip Milgram will conduct a comprehensive evaluation to determine whether TPE is appropriate for your health goals.
TPE may be especially beneficial for patients who:
- Have not responded to conventional therapies
- Are seeking non-pharmaceutical options for inflammation and immune dysfunction
- Want to proactively reduce biological age and improve resilience
- Are recovering from Long COVID or chronic fatigue
- Are pursuing advanced longevity and performance optimization
Schedule a Consultation with Dr. Phillip Milgram
To learn more about Therapeutic Plasma Exchange and how it fits into your personalized care plan, contact AgeReversalMD today.
Price: $7,000