A New Era in Human Longevity Science
In a landmark clinical trial published in Aging Cell, researchers from Global Apheresis and the Buck Institute for Research on Aging have confirmed that Therapeutic Plasma Exchange (TPE)—especially when combined with Intravenous Immunoglobulin (IVIG)—can reverse biological age in humans. This is the first human study to demonstrate measurable age reversal using multi-omics analysis, marking a pivotal moment in the evolution of longevity medicine.
At AgeReversalMD, under the direction of Dr. Phillip Milgram, MD, this breakthrough validates the protocols already in use for immune reset, inflammation reduction, and age-related disease prevention. For patients seeking evidence-based age reversal, this study offers both scientific credibility and clinical hope.
The Problem: Aging as a Treatable Condition
Age-related diseases such as cardiovascular disease, diabetes, neurodegeneration, and immune dysfunction account for over 90% of healthcare costs in the United States—more than $4.1 trillion annually. While aging has traditionally been viewed as inevitable, emerging science suggests it is modifiable. The Circulate-powered trial asked a bold question: Can we reverse biological age in humans using a clinically available therapy?
The answer, according to the data, is yes.
Study Design: Multi-Omics Meets Clinical Intervention
The trial enrolled healthy adults over the age of 50 in a single-blinded, placebo-controlled study. Participants were divided into four groups:
- Group 1: TPE once a month for six months
- Group 2: TPE twice a month (same week) for three months
- Group 3: TPE with IVIG twice a month (same week) for three months
- Control Group: No TPE or IVIG (placebo)
Researchers used multi-omics profiling to assess biological age and immune function. This included:
- Epigenomics: DNA methylation patterns across 35 validated biological clocks
- Proteomics: Protein expression linked to inflammation and immune signaling
- Metabolomics: Cellular energy and metabolic activity
- Glycomics: Sugar molecule patterns tied to immune aging
- Immune cell composition: T-cell subsets, monocytes, and natural killer (NK) cells
This level of molecular analysis is unprecedented in human aging research and provides a comprehensive view of how TPE affects the body at every level.
Key Findings: Biological Age Reversal Confirmed
The results were striking:
- Group 3 (TPE + IVIG) showed an average 2.61-year reduction in biological age after just three sessions
- Inflammatory proteins and immune markers associated with aging were significantly reduced
- CD8 and CD4 naïve T cells—critical for immune surveillance—were rejuvenated
- Senescent immune cells, including NK cells and monocytes, were reduced
- Participants with elevated blood sugar and liver enzymes saw the greatest improvements
These findings suggest that TPE, especially when paired with IVIG, can reset the immune system, reduce systemic inflammation, and reverse molecular markers of aging.
Mechanism of Action: Why TPE + IVIG Works
TPE works by removing the plasma portion of the blood, which contains:
- Autoantibodies
- Pro-inflammatory cytokines
- Immune complexes
- Lipid and protein toxins
By replacing this plasma with albumin, the body receives a clean circulatory environment that supports cellular repair and immune recalibration.
IVIG complements this process by:
- Replenishing functional antibodies
- Modulating immune responses
- Reducing autoimmune activity
Together, TPE and IVIG create a dual-action protocol that not only removes harmful substances but also restores immune balance. This combination appears to be the key to reversing biological age.
Clinical Relevance: From Research to Practice
For clinicians like Dr. Phillip Milgram, MD, the study provides validation for protocols already in use at AgeReversalMD. Patients undergoing TPE at the clinic often report:
- Improved energy and stamina
- Reduced brain fog and enhanced cognition
- Better sleep and mood stability
- Decreased inflammatory markers
- Enhanced resilience to infection and stress
Now, with multi-omics data confirming biological age reversal, these outcomes can be understood not just as symptomatic improvements—but as molecular rejuvenation.
Implications for Longevity Medicine
This study marks a turning point in how aging is approached in clinical practice. Key implications include:
1. Aging as a Modifiable Biomarker
Rather than treating age-related diseases in isolation, clinicians can now target aging itself as a root cause. Biological age becomes a measurable, reversible marker.
2. Personalized Protocols
Multi-omics tracking allows for individualized treatment plans based on immune profile, metabolic status, and epigenetic age.
3. Integration with Other Therapies
TPE can be combined with NAD+ IV therapy, peptide protocols, hormone optimization, and regenerative modalities for synergistic effects.
4. Preventative Health Redefined
Patients in midlife can begin age-reversal protocols before disease onset, shifting the paradigm from reactive care to proactive longevity.
Who Benefits Most?
While all participants showed improvement, those with elevated inflammatory markers, metabolic dysfunction, or immune imbalance benefited most. This includes:
- Adults over 50 with signs of immune aging
- Individuals with chronic inflammation or autoimmune conditions
- Patients recovering from viral illness or immune suppression
- Health-conscious individuals seeking preventative age-reversal
At AgeReversalMD, Dr. Milgram uses these insights to guide patient selection and protocol design—ensuring that each treatment is tailored for maximum impact.
Safety and Accessibility
TPE has been used clinically for over 50 years and is FDA-cleared for multiple indications. IVIG is also widely used in hospitals for immune modulation. The combination, when administered by trained professionals, is safe and well-tolerated.
Potential side effects include:
- Mild hypotension
- Fatigue or chills
- Temporary electrolyte shifts
- Rare allergic reactions
At AgeReversalMD, every session is monitored by experienced staff, with protocols adjusted for comfort and safety.
The Future of Age Reversal
The Global Apheresis and Buck Institute study opens the door to a new era of human health. For the first time, a clinically available therapy has been shown to reverse biological age in humans using rigorous molecular analysis.
This is not speculative science—it is actionable medicine.
As more clinics adopt multi-omics tracking and personalized TPE protocols, patients will gain access to therapies that not only treat disease but restore youth at the cellular level.
Dr. Phillip Milgram and the team at AgeReversalMD are proud to be at the forefront of this movement, offering patients the opportunity to reclaim vitality, resilience, and time.
Schedule Your Consultation
If you’re ready to explore San Diego Therapeutic Plasma Exchange as part of your age-reversal journey, contact AgeReversalMD today.
Let science guide your next chapter—starting at the cellular level.